Matt Kaeberlein
Professor of laboratory medicine and pathology at the University of Washington in Seattle. Director of the Dog Aging Project.
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Rapamycin: The Gold Standard For Longevity Interventions (4:36) Oct 31, 2022. Rapamycin is the most effective drug for increasing lifespan and improving healthspan in laboratory animals. Rapamycin is a small molecule that inhibits a protein called mTOR. Every animal and every eukaryotic cell we know of has mTOR.
Matt Kaeberlein | Rapamycin as the gold standard of Longevity Intervention (6:27) November 24, 2021. Lifespan increased in all models tested, yeast, worms, flies, and mice. Genetically turning down mTORC1 also increases lifespan. Robust and reproducible compared to NR and sirtuin activators. 9 to 30% extension. Not tested as extensively as caloric restriction. Improvements in immune, brain, heart, and oral cavity. Works on young and old mice. 2009 Intervention Testing Program study first to show effect on old mice.
Risk-reward ration in diets to slow aging (3:20) Feb 5, 2022. Health benefits of caloric restriction but possibly greater infection risk. Dr. Roy Walford, author of the 120-year Diet [1986], died at 79 of ALS. No evidence anyone following the caloric restriction program of the 120-year Diet lived to 110.
TOP 6 LIFE Extension Interventions In Science Studies | Dr Matt Kaeberlein Interview Clips (2:03) Aug 19, 2022. 6 mouse studies compared. Severe (65%) calorie restriction most effective at extending average lifespan. Rapamycin most robust and reproducible pharmacological intervention. Important to find effective interventions.
Dog Aging Project: Longevity and Rapamycin Studies in Pet Dogs | Matt Kaeberlein (7:43) Jan 16, 2022. Longitudinal study of aging. 33,000 dogs. Survey and veterinary records to find genetic and environmental determinants of health outcomes. 10,000 dogs have genomes sequenced. 1,000 dogs have annual medical tests. 500 dogs (7+ years old, 40+ pounds) given rapamycin or placebo for one year. 3 year observation period.
The Gerontological Society of America 2020 Robert W. Kleemeier Award: Matt R. Kaeberlein (4:52) Nov 5, 2020. Excited and optimistic about the future of aging research. The most important area of biomedical research today.