James Kirkland MD

Senolytics Human Trials – Intro & Dosing Regimen | Dr James Kirkland Interview Clips (6:52) Sep 1, 2022. Discussion of a pharmaceutical, quercetin, and fisetin used as senolytics. ‘Hit and run’ dosage. Alzheimer’s trial and Covid trial to evaluate the effectiveness of senolytics.

Senescent Cells Trial of Astronaut In Space Trip | Dr James Kirkland Interview Clips (1:51) Aug 13, 2022. Lots of DNA damage from flying. Astronauts, pilots, and flight attendants dying earlier. Solar radiation beyond the Van Allen belt 20 times more damaging than x-rays. Mission to Mars not possible unless we can deal with senescent cells.

Lifestyles To Reduce Senescent Burden & Measuring Panel | Dr. James Kirkland Interview Series Ep 5 (8:00) Jul 16, 2021. Obesity and diabetes. Exercise. Radiation. Smoking. Consortium of universities and other researchers measure a panel of biomarkers in trial patients taking senolytics, metformin, rapamycin, nad precursors. Blood, cheek swabs, urine, biopsies, microbiome. Same blood markers across trials. Epigenetic clock from cheek swabs. Effects on other pillars of aging. Trials of obesity and diabetes, Alzheimer’s, childhood cancer survivors, frailty, osteoporosis. Looking for best biomarkers to measure the response to an intervention.

Drug cocktail could extend your life, killing cells related to aging (3:05) Sep 20, 2018. Senescent cells cause damage and spread senescence but in small numbers defend against cancer. Frail elderly have more senescent cells. Drug cocktail can combat senescent cells. Advice viewer not to take until we do trials.