NMN Supplements

NAD (nicotinamide adenine dinucleotide) is a molecule found in most of the trillions of cells in our bodies. NAD plays many critical roles including energy production, DNA repair, and sleep regulation. Unfortunately NAD levels fall as we age. NAD boosters (e.g., NMN (nicotinamide mononucleotide), NR (nicotinamide riboside) and niacin), TMG, CD38 inhibitors (e.g., apigenin), and senolytics (e.g., fisetin and quercetin) are possible ways to maintain healthy NAD levels.

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NAD+ boosters: NR, NMN, and how they affect sirtuins | David Sinclair (3:40) Dec 10, 2019. Rhonda Patrick interviews David Sinclair. Want a stable epigenome. NAD (nicotinamide adenine dinucleotide) too large to enter cells. NAD precursors (NMN and NR) able to enter cells. Nampt enzyme converts precursors to NAD. Nampt goes up under stress and calorie restriction. NMN and NR shown to increase NAD levels in animals and humans.

6th NMN Human Study | Finally Good Quality (8:18) May 3, 2022. Study titled Oral administration of nicotinamide mononucleotide is safe and efficiently increases blood nicotinamide adenine dinucleotide levels in healthy subjects published April 11, 2022 in Frontiers in Nutrition. Placebo-controlled, randomized, double blind. 30 healthy volunteers (15 NMN, 15 placebo) administered 250 mg/day for 12 weeks. No significant adverse events in either group. Blood levels of NMN significantly increased after 12 weeks in NMN group. Controversy about how NMN is absorbed. Highest level of NMN observed at 4 weeks.

Does NAD+ Actually boost longevity? | Dr. Matt Kaeberlein (7:07) Mar 22, 2022. As a grad student in Lenny Guerent’s lab discovered that over expressing Sir2 in yeast extended their lives. Lives of worms and flies also extended. Mammals have 7 sirtuins. Extending mice lives by over expressing sirtuins not so successful. Does taking NAD boosters extend human life? Not convinced it does. Mouse study showing significant life extension had really short-lived controls. Interventions Testing Program showed no life extension with NR.

TMG

TMG (trimethylglycine) is a beet extract that supplies methyl needed for chemical reactions. NAD precursors, such as NMN, NR, and niacin, may deplete methyl and cause harm without an adequate supply of methyl.

What Is TMG (Trimethylglycine) (3:16) Jun 29, 2011. Lowers homocysteine, a precursor of heart and other diseases. Adds methyl groups which assist neurotransmitters to change emotions. Also assists memory and the liver. An extract from beets, a natural whole food.

NIACIN & NMN Causes DAMAGE | Trimethylglycine (TMG) Fix 2020 (11:58) Jun 17, 2020. Methylation (transfer of a methyl group from one molecule to another) needed for neurotransmitters and antioxidants. NMN depletes methyl groups and increases homocysteine, a risk factor for heart disease. TMG is safe, reduces homocysteine, and has other benefits.

NAD test kit

Testing NAD levels is important to determine if supplementation is necessary or working.

NAD+ Before & After | My Home Test Kit Experience (5:07) Jun 6, 2021. Fiancee’s NAD levels tested before and after one month of taking nmn.

How To Test Your NAD Levels (7:46) May 29, 2021. DoNotAge CEO provides a step by step guide to providing blood samples to have your NAD levels tested.

NAD LEVELS – How We Test & Decide The Optimal Range | Prof Jin-Xiong She Interview Series Episode 2 (18:58) June 17, 2021. NAD test to determine if NAD boosters and senolytics are working. 2 types of NAD: intracellular (inside cells) and circulating (in blood). For most people NAD levels do not fluctuate much by time of day. The optimal level of NAD is a minimum of 34 micromoles. 75% of people under 20 have NAD levels of 34 micromoles or higher. By people’s seventh decade the mean level is one-third of 34. Supplements can help. Too much NAD possible with IV infusions.