Apigenin Supplement

NAD (nicotinamide adenine dinucleotide) in cells is vital for energy production and life. NAD levels fall as we age. CD38 levels rise and degrade NAD. Apigenin, found in foods, especially parsley, and supplements, has been found in mice studies to reduce CD38 levels and increase NAD levels.

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My Road to Maximize Lifespan – Optimize NAD & Inhibit CD38 | Dr. Michael Lustgarten | Part V (8:00) Nov 25, 2020. NAD declines with age. NMN and NR work in people with BMI<25 but not in the obese. CD38 is a protein that increases with age and degrades NAD, NMN, and NR. Soluble fiber may improve gut barrier function and decrease CD38. Microbial Burden book by Lustgarten. Another approach to decrease CD38 is apigenin. Prefers blending fresh parsley in a smoothie to supplements. Biological age tests. Show me the data.

3 Ways to Raise NAD & Lower CD38 (8:17) Sep 28, 2020. As we age NAD decreases and CD38 increases. CD38 inhibits NAD for a double whammy. NAD is a vital molecule inside cells. NAD levels can be raised with NMN, NR, diet, exercise, and fasting. Apigenin and quercetin inhibit CD38 activity. As levels increase, CD38 activity decreases resulting in higher NAD levels. Parsley and other foods have apigenin. Dried forms may have better bioavailability. Two pronged attack: raise NAD with NR or NMN, reduce CD38 with quercetin and apigenin. Accelerator-brake analogy.

Apigenin For Anti-Aging | Better Than NMN In 2021? (9:42) Feb 1, 2021. NAD is a molecule used in mitochondrial function and DNA repair. CD38 is a protein that increases with age and may be responsible for decreasing NAD levels. In mice with CD38 levels knocked out NAD levels remained constant and life extended. Apigenin is a flavonoid found in plants and found to reduce CD38 levels. Mice study found benefits for glucose levels, coronary plaque, and cancer. Appears we can get apigenin from food into our bloodstream. Couldn’t get enough apigenin from diet so plans to take supplements.

APIGENIN Supplement & Senescence | ANTI AGING Method In 2020 (10:41) Jun 29, 2020. Apigenin found in parsley and chamomile tea. Decrease of NAD+ levels as we age may be caused by increasing CD38 levels. Apigenin, a flavonoid, found to inhibit CD38. Evidence that apigenin may help against obesity, diabetes, atherosclerosis, and cancer. Dried parsley has apigenin levels far exceeding other plants. Plants have fiber and other nutrients not in supplements.

RAISE NAD+ WITH APIGENIN & QUERCETIN: Reduce CD38 To Boost NAD+ Levels [2021] (15:02) Apr 13, 2021. CD38 is a protein found on immune cells like T and B cells. NAD is a derivative of niacin involved in over 500 reaction and present in every living cell on earth. Loss of NAD believed a major cause of aging. Rise of CD38 appears to cause the loss of NAD. Senescent cells may cause the rise of CD38. Senolytics (e.g., fisetin, quercetin) to clear senescent cells. Apigenin and quercetin the most effective CD38 inhibitors. Dried parsley 10x more apigenin than fresh. Need to eat lots of dried parsley. Bioavailability issues with apigenin and quercetin.